Department of Radiology, Peking University First Hospital, Beijing, 100034, China.
Department of Neurology, Peking University First Hospital, Beijing, 100034, China.
Curr Med Sci. 2019 Feb;39(1):138-145. doi: 10.1007/s11596-019-2012-8. Epub 2019 Mar 13.
Quantitative magnetic resonance image (MRI) in individual muscles may be useful for monitoring disease progression in Duchenne muscular dystrophy (DMD). The purpose of this study was to measure T2 relaxation time of thigh muscles in children with DMD and healthy boys, and to correlate the T2 relaxation time of muscles with the fat fraction (FF) at quantitative magnetic resonance and results of clinical assessment. Thirty-two boys with DMD and 18 healthy boys were evaluated with T2 mapping and three-point Dixon MRI. Age, body mass index (BMI), muscle strength assessment, timed functional tests (time to walk or run 10 metres, rise from the floor and ascend four stairs), and the North Star Ambulatory Assessment (NSAA) were evaluated. Spearman's correlation was used to assess the relationships between FF and clinical assessments and T2 relaxation time. The mean T2 relaxation time of thigh muscles in DMD was significantly longer than that in the control group (P<0.05), except for the gracilis (P=0.952). The gracilis, sartorius and adductor longus were relatively spared by fatty infiltration in DMD patients. The T2 relaxation time was correlated significantly with the mean FF in all muscles. Age, BMI, total muscle strength score, timed functional tests and NSAA were significantly correlated with the overall mean T2 relaxation time. T2 mapping may prove clinically useful in monitoring muscle changes as a result of the disease process and in predicting the outcome of DMD patients.
定量磁共振成像（MRI）在单个肌肉中的应用可能有助于监测杜氏肌营养不良症（DMD）的疾病进展。本研究的目的是测量 DMD 患儿和健康男孩大腿肌肉的 T2 弛豫时间，并将肌肉的 T2 弛豫时间与定量磁共振的脂肪分数（FF）以及临床评估结果相关联。对 32 名 DMD 男孩和 18 名健康男孩进行 T2 映射和三点 Dixon MRI 评估。评估了年龄、体重指数（BMI）、肌肉力量评估、计时功能测试（走或跑 10 米的时间、从地板上站起来并爬上四级楼梯）以及北极星日常活动评估（NSAA）。使用 Spearman 相关分析评估 FF 与临床评估和 T2 弛豫时间之间的关系。DMD 患者大腿肌肉的 T2 弛豫时间明显长于对照组（P<0.05），除了比目鱼肌（P=0.952）。DMD 患者的比目鱼肌、缝匠肌和长收肌相对不受脂肪浸润的影响。T2 弛豫时间与所有肌肉的平均 FF 显著相关。年龄、BMI、总肌肉力量评分、计时功能测试和 NSAA 与整体平均 T2 弛豫时间显著相关。T2 映射可能在监测疾病过程中肌肉变化以及预测 DMD 患者的预后方面具有临床应用价值。
