免疫抑制后神经皮肤黑素沉着症（NCM）的恶性转化
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.
作者信息
Schaff Lauren R, Marghoob Ashfaq, Rosenblum Marc K, Meyer Rina, Khakoo Yasmin
机构信息
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Department of Dermatology, Memorial Sloan Kettering Cancer Center, New York City, New York.
出版信息
Pediatr Dermatol. 2019 Jul;36(4):497-500. doi: 10.1111/pde.13804. Epub 2019 Mar 13.
Abstract
Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. To our knowledge, this is the first reported case of a patient with known NCM undergoing malignant transformation after anti-TNF therapy for inflammatory bowel disease.
摘要
神经皮肤黑素沉着症（NCM）是一种软脑膜和脑实质中黑素细胞异常沉积的病症。NCM与先天性黑素细胞痣相关，可导致神经功能缺损、脑积水，细胞恶变则较为罕见。我们报告了一例16岁患有NCM的男孩病例，该男孩在使用肿瘤坏死因子α抑制剂进行免疫抑制治疗后发生了恶性软脑膜黑色素瘤。据我们所知，这是首例已知患有NCM的患者在接受抗TNF治疗炎性肠病后发生恶变的病例报告。
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