Afacan-Öztürk Hacer B, Falay Mesude, Albayrak Murat, Yıldız Abdulkerim, Öztürk Ҫiğdem Pala, Maral Senem, Özet Gülsüm
Clin Lab. 2019 Mar 1;65(3). doi: 10.7754/Clin.Lab.2018.180802.
Immunophenotyping has a central role in CLL. However, CLL is a very heterogenous disease, both morphologically and immunophenotypically; thus, its diagnosis may prove a challenge. We investigated CD81 ex-pression in the differential diagnosis of CLL and MCL.
We retrospectively examined CD81 expression with 8 color Multiparameter Flow cytometry devices in 101 CLL and 19 MCL cases.
We found negative CD81 expression in CLL cases whereas it was positive in MCL cases.
Our results suggest that CD81 may be a valuable marker for the differential diagnosis of CLL. We are of the opinion that it should be definitely included in the diagnostic algorithm for CLL.
免疫表型分析在慢性淋巴细胞白血病（CLL）中起着核心作用。然而，CLL在形态学和免疫表型上都是一种非常异质性的疾病；因此，其诊断可能具有挑战性。我们研究了CD81表达在CLL和套细胞淋巴瘤（MCL）鉴别诊断中的作用。
我们回顾性地用8色多参数流式细胞仪检测了101例CLL和19例MCL病例中的CD81表达。
我们发现CLL病例中CD81表达为阴性，而MCL病例中为阳性。
我们的结果表明，CD81可能是CLL鉴别诊断的一个有价值的标志物。我们认为它应明确纳入CLL的诊断算法中。
