Fang Wan-Yin, Qin Hua-Li
State Key Laboratory of Silicate Materials for Architectures and School of Chemistry, Chemical Engineering, and Life Science , Wuhan University of Technology , 205 Luoshi Road , Wuhan 430070 , P. R. China.
J Org Chem. 2019 May 3;84(9):5803-5812. doi: 10.1021/acs.joc.8b03164. Epub 2019 Apr 4.
A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NHOH/NaCO/SOF) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.
开发了一种简单、温和且实用的将醛直接转化为腈的方法，该方法使用无机试剂（NHOH/NaCO/SOF）在二甲基亚砜（DMSO）中，底物范围广泛，对官能团耐受性强（52个实例，大多数情况下产率超过90%）。该方法能够以一锅法、原子经济性和步骤经济性的方式，在无过渡金属的情况下，将容易获得、廉价且丰富的醛转化为高价值的腈。该方案将成为一种用于将氰基部分引入复杂分子的强大工具。
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