由硫酰氟（SOF）介导，从环丁酮肟合成脂肪腈。
Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SOF).
作者信息
Chen Xian-Lin, Qin Hua-Li
机构信息
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China.
出版信息
Beilstein J Org Chem. 2023 Jun 22;19:901-908. doi: 10.3762/bjoc.19.68. eCollection 2023.
Abstract
A SOF-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with ()-configuration selectivity. This new method features wide substrate scope, mild conditions, and direct N-O activation.
摘要
开发了一种由索非布韦介导的环丁酮肟衍生物与烯烃的开环交叉偶联反应，用于构建一系列具有（）-构型选择性的含δ-烯烃脂肪腈。这种新方法具有底物范围广、条件温和以及直接N-O活化的特点。
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