6-羟基多巴胺或5,7-二羟基色胺对成年或新生动物进行治疗后对运动活性、单胺水平及咖啡因反应的影响。

Effects of adult or neonatal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine on locomotor activity, monoamine levels, and response to caffeine.

作者信息

Erinoff L, Snodgrass S R

出版信息

Pharmacol Biochem Behav. 1986 Apr;24(4):1039-45. doi: 10.1016/0091-3057(86)90453-3.

Abstract

Rats were treated as neonates or adults with desmethylimipramine (DMI) followed by intraventricular 6-hydroxydopamine (6-HDA) or 5,7 dihydroxytryptamine (5,7-DHT). Locomotor activity of treated rats was measured in photocell cages. Neonatal treatment with 5,7-DHT produced hypoactivity during development while neonatal 6-HDA led to hyperactivity. Treatment of adult rats with 5,7-DHT or 6-HDA, while resulting in equivalent monoamine depletions, was without effect on locomotor activity. The dose response function for caffeine was determined in these rats. Depletion of dopamine by either neonatal or adult treatment with 6-HDA decreased caffeine stimulation of locomotor activity. The adenosine receptor agonist l-phenylisopropyladenosine (L-PIA) decreased locomotor activity in all rats in a dose-dependent fashion.

摘要

将新生大鼠或成年大鼠用去甲丙咪嗪（DMI）处理，随后进行脑室内注射6-羟基多巴胺（6-HDA）或5,7-二羟基色胺（5,7-DHT）。在光电笼中测量处理后大鼠的运动活性。新生期用5,7-DHT处理会导致发育过程中活动减少，而新生期用6-HDA处理则导致活动亢进。成年大鼠用5,7-DHT或6-HDA处理，虽然导致等量的单胺耗竭，但对运动活性没有影响。在这些大鼠中测定了咖啡因的剂量反应函数。新生期或成年期用6-HDA处理导致多巴胺耗竭，会降低咖啡因对运动活性的刺激作用。腺苷受体激动剂1-苯基异丙基腺苷（L-PIA）以剂量依赖的方式降低所有大鼠的运动活性。