Keirse M J, Erwich J J, Klok G
Prostaglandins. 1986 Mar;31(3):527-34. doi: 10.1016/0090-6980(86)90114-0.
Prostaglandin endoperoxide synthase (i.e. cyclooxygenase; PGH synthase) and prostacyclin synthase (PGI synthase) were quantitated with specific immunoradiometric assays in microsomes from human placentae (n = 20) obtained from 7 up to 17 weeks of gestation. Over that period, wherein trophoblastic invasion of the uterine spiral arteries occurs, the placentae showed a significant increase in concentrations of PGH synthase (r = 0.73, p less than 0.001; n = 20), but not in those of PGI synthase. While the variation between individual placentae was much larger for PGI synthase than for PGH synthase concentrations, there was no evidence for a large excess of PGI synthase over that of PGH synthase in any of these early placentae. The data indicate, first, that the developing placenta contains PGI synthase, but in amounts which are relatively small and do not appear to increase with advancing gestation. Second, they seem to indicate that the capacity for bioconversion of arachidonic acid into prostaglandin endoperoxides increases markedly with placental development.
采用特异性免疫放射分析法定量测定了妊娠7至17周获取的人胎盘（n = 20）微粒体中的前列腺素内过氧化物合酶（即环氧化酶；PGH合酶）和前列环素合酶（PGI合酶）。在那段时间，即发生子宫螺旋动脉滋养层浸润期间，胎盘的PGH合酶浓度显著增加（r = 0.73，p < 0.001；n = 20），但PGI合酶浓度未增加。虽然PGI合酶的个体胎盘间差异比PGH合酶浓度的个体胎盘间差异大得多，但在这些早期胎盘中，没有证据表明PGI合酶大大超过PGH合酶。数据首先表明，发育中的胎盘含有PGI合酶，但含量相对较少，且似乎不会随着妊娠进展而增加。其次，数据似乎表明，随着胎盘发育，花生四烯酸生物转化为前列腺素内过氧化物的能力显著增加。
