Rosanova María T, Mussini María S, Arias Ana P, Sormani María I, Mastroianni Alejandra, García María E, Reijtman Vanesa, Sarkis Claudia
Servicio de Control Epidemiológico e Infectología. Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires.
Servicio de Microbiología. Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires.
Arch Argent Pediatr. 2019 Apr 1;117(2):128-131. doi: 10.5546/aap.2019.eng.128.
The objective was to describe the epidemiological, clinical, microbiological, and evolutionary characteristics and the risk factors for mortality. Retrospective, cohort study. A total of 100 patients were included. Of these, 42 (42 %) had septic shock upon admission and 56 (56 %) were admitted to the intensive care unit. Bacteremia was primary in 17 patients (17 %); catheter-related, in 15 (15 %); and secondary, in 68 (68 %). The most common source of infection was the skin and mucous membrane. Resistance to one or more antibiotic groups was 38 %. Thirty-one patients died (31 %). Risk factors for mortality were septic shock (p < 0.0005), admission to the intensive care unit (p < 0.0001), primary bacteremia (p < 0.009) or secondary, non-catheter-related bacteremia (p < 0.003), presence of mucocutaneous or pulmonary source of infection (p < 0.004), and multidrug resistance (p < 0.01) or resistance to carbapenems (p < 0.01).
目的是描述其流行病学、临床、微生物学及演变特征以及死亡风险因素。回顾性队列研究。共纳入100例患者。其中，42例（42%）入院时患有感染性休克，56例（56%）入住重症监护病房。17例（17%）为原发性菌血症；15例（15%）与导管相关；68例（68%）为继发性菌血症。最常见的感染源是皮肤和黏膜。对一种或多种抗生素组耐药的比例为38%。31例患者死亡（31%）。死亡风险因素包括感染性休克（p < 0.0005）、入住重症监护病房（p < 0.0001）、原发性菌血症（p < 0.009）或继发性非导管相关菌血症（p < 0.003）、存在皮肤黏膜或肺部感染源（p < 0.004）以及多重耐药（p < 0.01）或对碳青霉烯类耐药（p < 0.01）。
