精准预防：对医疗保健领域范式转变的针对性应对。
Precision prevention: A focused response to shifting paradigms in healthcare.
机构信息
1 Department of Medicine, Division of Clinical Data Analytics and Decision Support, University of Arizona College of Medicine - Phoenix, AZ 85004, USA.
2 Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona College of Medicine - Tucson, AZ 85724, USA.
出版信息
Exp Biol Med (Maywood). 2019 Mar;244(3):207-212. doi: 10.1177/1535370219829759.
Abstract
The study of LINE-1 retroelements and their role in the pathogenesis of diseases of the lung such as COPD and lung cancer may provide valuable diagnostic and therapeutic tools to identify pre-emptively individuals at risk of pulmonary disease progression. Limited information is presently available on the role of LINE-1 in the regulation of disease phenotypes and the development of novel therapeutics designed to curtail LINE-1-mediated pathogenesis. Successful implementation of precision prevention strategies may help to spare those impacted by obstructive pulmonary disease from continued deterioration, while realizing significant cost savings and improved quality of healthcare.
摘要
LINE-1 逆转录元件及其在 COPD 和肺癌等肺部疾病发病机制中的作用的研究，可能为识别有肺部疾病进展风险的个体提供有价值的诊断和治疗工具。目前关于 LINE-1 在疾病表型调控和设计新型治疗方法以遏制 LINE-1 介导的发病机制中的作用的信息有限。成功实施精准预防策略可能有助于使受阻塞性肺病影响的患者免于持续恶化，同时实现显著的成本节约和改善医疗保健质量。
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