MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.
Chem Commun (Camb). 2019 Mar 26;55(26):3833-3836. doi: 10.1039/c9cc00882a.
Multidrug resistance mediated by the overexpression of ABC transporters is a major challenge in cancer chemotherapy. Here, we report the synthesis of an organoruthenium complex, RuF, that was designed to surmount multidrug resistance by combining ABCG2 inhibition and cancer cell cytotoxicity, yielding synergistic efficacy.
多药耐药性通过 ABC 转运蛋白的过度表达介导，是癌症化疗的主要挑战。在这里，我们报告了一种有机钌配合物 RuF 的合成，该配合物旨在通过结合 ABCG2 抑制和癌细胞细胞毒性来克服多药耐药性，产生协同疗效。
