National & Local United Engineering Laboratory for Power Battery, Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
Chem Commun (Camb). 2019 Mar 26;55(26):3821-3824. doi: 10.1039/c9cc01257e.
A novel base-mediated regioselective [3+2] annulation of active methylene isocyanides with ketenimines has been developed. In the presence of t-BuOK, a wide range of ketenimines readily react with active methylene isocyanides in DMF at 40 °C to afford 1,4,5-trisubstituted imidazoles efficiently.
一种新型的基于碱基的区域选择性[3+2]环加成反应，将活性亚甲基异氰化物与烯酮亚胺反应，已经被开发出来。在 t-BuOK 的存在下，各种烯酮亚胺在 DMF 中于 40°C 下与活性亚甲基异氰化物反应，高效地得到 1,4,5-三取代的咪唑。
