Abdel-Salam E, Abdel Khalik A, Abdel-Meguid A, Barakat W, Mahmoud A A
Tissue Antigens. 1986 Mar;27(3):142-6. doi: 10.1111/j.1399-0039.1986.tb01513.x.
The present study was designed to examine the possible association of HLA antigens and schistosomal hepatosplenomegaly and colonic polyposis in a large number of patients and controls. The results show that hepatosplenomegaly was significantly associated with the presence of two HLA antigens: HLA-A1 and B5; and colonic polyposis to HLA-B5 and B8. Furthermore, asymptomatic infection was significantly seen more in subjects with CW2. These results point to possible gentic factors controlling the pathogenesis of disease and susceptibility to infection in human schistosomiasis.
本研究旨在检测大量患者和对照人群中HLA抗原与血吸虫性肝脾肿大及结肠息肉病之间可能存在的关联。结果显示，肝脾肿大与两种HLA抗原的存在显著相关：HLA-A1和B5；结肠息肉病与HLA-B5和B8相关。此外，携带CW2的受试者无症状感染更为显著。这些结果表明，可能存在遗传因素控制人类血吸虫病的发病机制和对感染的易感性。
