Bondarenko A L, Baramzina S V
State Medical Academy, Kirov, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2002 Mar-Apr(2):55-7.
Clinical, biochemical and immunological parameters depending on HLA-phenotypic features were examined in 107 patients aged 18-78 years with chronic hepatitis C virus (HCV) infection. Clinical and biochemical manifestations (asthenic, pain and cytolytic syndromes, hepatomegalia, hyperbilirubinemia, hypoprothrombin- and proteinemia), observed in hepatitis C, were more pronounced in patients having HLA-A30, B35, B41, Cw2, A1-B35, A9-B8. The carriers of B8 and B35 antigens were found to have inadequate immune response in HCV infection, manifested by progressive chronic process in the liver and the development of cirrhosis in patients with such specificity.
对107例年龄在18 - 78岁的慢性丙型肝炎病毒（HCV）感染患者，根据HLA表型特征检查了临床、生化和免疫参数。丙型肝炎中观察到的临床和生化表现（乏力、疼痛和细胞溶解综合征、肝肿大、高胆红素血症、低凝血酶原血症和低蛋白血症），在具有HLA - A30、B35、B41、Cw2、A1 - B35、A9 - B8的患者中更为明显。发现B8和B35抗原携带者在HCV感染中存在免疫反应不足，表现为肝脏进行性慢性病变，以及具有这种特异性的患者发生肝硬化。
