Van Stee E W, Simmons J E, Sloane R A, Moorman M P, Adkins B, Cockrell B Y
Toxicology. 1986 Jul;40(1):45-58. doi: 10.1016/0300-483x(86)90045-4.
Exposure of rabbits for 12 weeks to 300 ppm carbon disulfide (CS2) for 6 h/day, 5 days/week, or to 25 mg/day of thiourea or 2% cholesterol in the diet, or to any combination thereof caused a significant reduction in the concentration of serum thyroxine (T4). The reduction of the concentration of serum T4 in rabbits by the treatments was completely offset by the inclusion of 0.1 mg/day of sodium levothyroxine in the diet. Ingestion of feed containing 2% cholesterol significantly increased the degree of atherosclerosis present in the aortic arch and significantly increased the oil red O positive lipid present in the heart and the aorta, with the aortic arch being the most severely affected. The response of the aorta and the heart to the 2% cholesterol diet was not significantly modified by concurrent exposure to CS2 by inhalation or by treatment with thiourea, a metabolite of CS2. We found no evidence that the development of cardiovascular lesions induced by a 2% cholesterol diet in rabbits was mediated by a mechanism involving a component of hypothyroidism.
将兔子每周5天、每天6小时暴露于300 ppm二硫化碳（CS2）中12周，或在饮食中给予每天25 mg硫脲或2%胆固醇，或给予上述任何组合，均会导致血清甲状腺素（T4）浓度显著降低。通过在饮食中添加每天0.1 mg左甲状腺素钠，可完全抵消这些处理对兔子血清T4浓度的降低作用。摄入含2%胆固醇的饲料会显著增加主动脉弓处动脉粥样硬化的程度，并显著增加心脏和主动脉中油红O阳性脂质的含量，其中主动脉弓受影响最为严重。同时通过吸入CS2或用CS2的代谢产物硫脲进行处理，并不会显著改变主动脉和心脏对2%胆固醇饮食的反应。我们没有发现证据表明，兔子食用2%胆固醇饮食所诱发的心血管病变是由涉及甲状腺功能减退的机制介导的。
