Central Research Laboratory, Hamamatsu Photonics K. K., Hamamatsu, Japan. Faculty of Engineering, University of Fukui, Fukui, Japan. 5000, Hirakuchi, Hamakita-ku, Hamamatsu, 434-8601 Japan. Author to whom any correspondence should be addressed.
Phys Med Biol. 2019 Mar 29;64(7):07LT01. doi: 10.1088/1361-6560/ab0fce.
Radiation detectors dedicated to time-of-flight positron emission tomography (PET) have been developed, and coincidence time resolution (CTR) of sub-100 ps full width at half maximum (FWHM) has been achieved by carefully optimizing scintillators and photodetectors. Achieving a CTR of 30 ps FWHM by using a pair of annihilation γ-rays would allow us to directly localize the annihilation point within an accuracy of 4.5 mm. Such direct localization can potentially eliminate the requirement of image reconstruction processes in clinical PET systems, which would have a huge impact on clinical protocols and molecular imaging. To obtain such a high CTR, researchers have investigated the use of prompt emissions such as Cherenkov radiation and hot-intra band luminescence. Although it is still challenging to achieve a CTR of 30 ps FWHM even with a Cherenkov-based detector, the experimentally measured CTR is approaching the goal. In this work, we developed a Cherenkov-radiator-integrated micro-channel plate photomultiplier tube (CRI-MCP-PMT), where there are no optical boundaries between the radiator and photocathode, and its timing performance was investigated. By removing the optical boundaries, reflections are eliminated and transmission to the photocathode is improved, resulting in high timing capability. As a result, a CTR of 30.1 ± 2.4 ps FWHM, which is equivalent to a position resolution of 4.5 ± 0.3 mm along a line of response (LOR), was obtained by using a pair of CRI-MCP-PMTs.
已经开发出了专门用于飞行时间正电子发射断层扫描(PET)的辐射探测器,并通过仔细优化闪烁体和光电探测器,实现了小于 100 ps 半高全宽(FWHM)的符合时间分辨率(CTR)。通过使用一对湮没γ射线实现 30 ps FWHM 的 CTR,可以使我们能够直接将湮没点定位在 4.5mm 的精度内。这种直接定位有可能消除临床 PET 系统中图像重建过程的要求,这将对临床方案和分子成像产生巨大影响。为了获得如此高的 CTR,研究人员研究了使用契伦科夫辐射和热带内带发光等瞬时发射。尽管使用基于契伦科夫的探测器实现 30 ps FWHM 的 CTR 仍然具有挑战性,但实验测量的 CTR 正在接近目标。在这项工作中,我们开发了一种契伦科夫辐射体集成微通道板光电倍增管(CRI-MCP-PMT),其中辐射体和光电阴极之间没有光学边界,并且研究了其定时性能。通过消除光学边界,可以消除反射并提高对光电阴极的传输,从而实现高定时能力。结果,使用一对 CRI-MCP-PMT 获得了 30.1 ± 2.4 ps FWHM 的 CTR,这相当于在响应线(LOR)上具有 4.5 ± 0.3 mm 的位置分辨率。