de Oliveira Cristina Mendes, Fregnani José Humberto T G, Villa Luisa Lina
HPV Research Group, Barretos Cancer Hospital, Barretos (SP), Brazil,
HPV Research Group, Barretos Cancer Hospital, Barretos (SP), Brazil.
Acta Cytol. 2019;63(2):159-168. doi: 10.1159/000497617. Epub 2019 Mar 14.
HPV is the most common sexually transmitted biological agent and is the cause of many conditions in men and women, including precancer lesions and cancer. Three prophylactic HPV vaccines targeting high-risk HPV types are available in many countries worldwide: 2-, 4- and 9-valent vaccines. All the 3 vaccines use recombinant DNA technology and are prepared from the purified L1 protein that self-assembles to form HPV type-specific empty shells. This non-systematic review aims to summarize the HPV epidemiology and the vaccine development to review the landmark trials of HPV vaccine, to present to most remarkable results from clinical trials and the real world, and to stress the challenges and the barriers for HPV vaccine implementation.
人乳头瘤病毒（HPV）是最常见的性传播生物病原体，是导致许多男性和女性疾病的原因，包括癌前病变和癌症。全球许多国家都有三种针对高危HPV类型的预防性HPV疫苗：二价、四价和九价疫苗。这三种疫苗均采用重组DNA技术，由纯化的L1蛋白制备而成，L1蛋白自组装形成HPV型特异性空壳。本非系统性综述旨在总结HPV流行病学和疫苗研发情况，回顾HPV疫苗的标志性试验，展示临床试验和现实世界中最显著的结果，并强调HPV疫苗实施面临的挑战和障碍。
