Lennmarken C, Larsson J
Acta Chir Scand. 1986 Mar;152:169-73.
Skeletal muscle function may be used to assess nutritional status. To approach this hypothesis nine malnourished surgical patients were studied at admission and after two weeks of preoperative total parenteral nutrition. The muscle function variables, force at 10 Hz stimulation (F10), relaxation rate (RR) and endurance (E) were determined. Energy metabolites were measured in muscle biopsies. At admission muscle function and content of energy-rich phosphates were normal, muscle glycogen was low and water was increased. After nutritional therapy, F10 and E were unchanged, RR was increased (p less than 0.05), glycogen was normalized, muscle water remained high while the nutritional markers prealbumin and skin test were markedly improved. In conclusion, skeletal muscle function and content of energy-rich phosphates were normal in semistarved malnourished patients. After nutritional therapy, RR was increased and this may prove useful in following the effect of nutritional repletion.
骨骼肌功能可用于评估营养状况。为验证这一假设，对9名营养不良的外科手术患者在入院时及术前两周全胃肠外营养后进行了研究。测定了肌肉功能变量，即10Hz刺激时的肌力（F10）、松弛速率（RR）和耐力（E）。在肌肉活检中测量了能量代谢产物。入院时肌肉功能及富含能量的磷酸盐含量正常，肌肉糖原含量低，水分增加。营养治疗后，F10和E未改变，RR增加（p<0.05），糖原恢复正常，肌肉水分仍较高，而营养指标前白蛋白和皮肤试验明显改善。总之，半饥饿营养不良患者的骨骼肌功能及富含能量的磷酸盐含量正常。营养治疗后，RR增加，这可能有助于追踪营养补充的效果。
