Newham D J, Harrison R A, Clark C G
Department of Surgery, University College London, Rayne Institute, UK.
Hum Nutr Clin Nutr. 1987 Sep;41(5):363-71.
The contractile properties of the adductor pollicis and quadriceps muscles have been studied before and 4 and 10 d after major abdominal surgery in 15 patients. Eight patients were considered well nourished and 7 malnourished on the grounds of body mass index, recent weight loss and serum albumin. There were no significant changes in the contractility of the adductor pollicis at 4 and 10 d post-operatively compared to pre-operative values. The only change in the quadriceps was seen in the malnourished patients and was a potentiation of the force:frequency relationship at day 4, affecting force generation at 1 Hz. There was a tendency for the malnourished patients to generate higher forces at low stimulation frequencies and to have slower relaxation rates, but there was no significant difference between the two groups. Pre-operative contractile properties of those patients who developed post-operative complications were not different from those who were free of complications, nor did the post-operative results of the two groups of patients differ. The patients generated higher forces at lower stimulation frequencies than is usually found in young normal subjects. This may be due to age, disease or nutritional factors, but it is not possible to determine the relative contributions of these factors from this study.
对15例患者拇收肌和股四头肌的收缩特性在腹部大手术前以及术后4天和10天进行了研究。根据体重指数、近期体重减轻情况和血清白蛋白水平，8例患者被认为营养良好，7例患者营养不良。与术前值相比，拇收肌术后4天和10天的收缩性没有显著变化。股四头肌的唯一变化见于营养不良患者，即在术后第4天力量-频率关系增强，影响1Hz时的力量产生。营养不良患者在低刺激频率下有产生更高力量的趋势，且放松速率较慢，但两组之间没有显著差异。发生术后并发症的患者术前收缩特性与未发生并发症的患者没有差异，两组患者的术后结果也没有差异。这些患者在较低刺激频率下产生的力量比年轻正常受试者通常产生的力量更高。这可能是由于年龄、疾病或营养因素，但从本研究中无法确定这些因素的相对作用。
