1 Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, People's Republic of China.
2 Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, People's Republic of China.
Angiology. 2019 Nov;70(10):960-968. doi: 10.1177/0003319719835637. Epub 2019 Mar 14.
There is a lack of studies that evaluate the association between normal weight central obesity and subsequent outcomes in patients with premature acute coronary syndrome (ACS). We evaluated 338 consecutive male patients (aged ≤ 55 years) with premature ACS. The primary outcomes were all-cause mortality and major adverse cardiac and cerebrovascular events (MACCE). We compared the hazard ratios (HRs) in patients with and without normal weight central obesity using multivariable Cox proportional hazard models. All-cause mortality (16.8%) of patients with normal weight central obesity was much higher than those (7.1%) without normal weight central obesity ( = .008). The incidence of MACCE in patients with and without normal weight central obesity were 40.7 and 23.6% ( = .001), respectively. After multivariable adjustment, the risks of all-cause mortality and MACCE were significantly higher in patients with normal weight central obesity than those without normal weight central obesity (adjusted HR: 1.83; 95% confidence interval [CI]: 1.04-3.31; = .004 and adjusted HR: 1.62; 95% CI: 1.18-2.27; = .017, respectively). In conclusion, the risks of all-cause mortality and MACCE were significantly higher in male patients with premature ACS with normal weight central obesity than in those without normal weight central obesity.
正常体重中心型肥胖与早发急性冠状动脉综合征患者预后的相关性研究较少。我们评估了 338 例连续的男性早发急性冠状动脉综合征患者（年龄≤55 岁）。主要终点是全因死亡率和主要不良心脑血管事件（MACCE）。我们使用多变量 Cox 比例风险模型比较了有和无正常体重中心型肥胖患者的风险比（HR）。正常体重中心型肥胖患者的全因死亡率（16.8%）明显高于无正常体重中心型肥胖患者（7.1%）（=.008）。有和无正常体重中心型肥胖患者的 MACCE 发生率分别为 40.7%和 23.6%（=.001）。多变量调整后，与无正常体重中心型肥胖患者相比，正常体重中心型肥胖患者的全因死亡率和 MACCE 风险显著更高（调整 HR：1.83；95%置信区间 [CI]：1.04-3.31；=.004 和调整 HR：1.62；95% CI：1.18-2.27；=.017，分别）。总之，与无正常体重中心型肥胖患者相比，早发急性冠状动脉综合征的男性患者中，正常体重中心型肥胖患者的全因死亡率和 MACCE 风险显著更高。
