Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, QC, Canada; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Trends Mol Med. 2019 Apr;25(4):257-259. doi: 10.1016/j.molmed.2019.02.011. Epub 2019 Mar 11.
Tumor migration is driven by actomyosin contractility. A recent publication by Georgouli et al. (Cell 2019;176:757-774) describes how crosstalk between the cell migration machinery and tumor-associated macrophages (TAMs) shapes the microenvironment to promote tumor growth. Indirectly targeting TAMs by inhibiting the motility of tumor cells could hinder metastatic spread.
肿瘤迁移是由肌动球蛋白收缩力驱动的。Georgouli 等人最近的一篇论文（Cell 2019;176:757-774）描述了细胞迁移机制与肿瘤相关巨噬细胞（TAMs）之间的相互作用如何塑造微环境以促进肿瘤生长。通过抑制肿瘤细胞的迁移来间接靶向 TAMs 可能会阻碍转移的扩散。
