Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China.
Front Immunol. 2024 Jan 8;14:1307228. doi: 10.3389/fimmu.2023.1307228. eCollection 2023.
Tumor metabolism and tumor immunity are inextricably linked. Targeting the metabolism of tumors is a point worth studying in tumor immunotherapy. Recently, the influence of the metabolism of tumors and immune cells on the occurrence, proliferation, metastasis, and prognosis of tumors has attracted more attention. Tumor tissue forms a specific tumor microenvironment (TME). In addition to tumor cells, there are also immune cells, stromal cells, and other cells in TME. To adapt to the environment, tumor cells go through the metabolism reprogramming of various substances. The metabolism reprogramming of tumor cells may further affect the formation of the tumor microenvironment and the function of a variety of cells, especially immune cells, eventually promoting tumor development. Therefore, it is necessary to study the metabolism of tumor cells and its effects on immune cells to guide tumor immunotherapy. Inhibiting tumor metabolism may restore immune balance and promote the immune response in tumors. This article will describe glucose metabolism, lipid metabolism, amino acid metabolism, and immune cells in tumors. Besides, the impact of metabolism on the immune cells in TME is also discussed for analyzing and exploring tumor immunotherapy.
肿瘤代谢与肿瘤免疫密切相关。针对肿瘤代谢的干预是肿瘤免疫治疗中值得研究的一个靶点。近年来，肿瘤和免疫细胞代谢对肿瘤发生、增殖、转移和预后的影响受到越来越多的关注。肿瘤组织形成了一个特定的肿瘤微环境（TME）。TME 除了肿瘤细胞外，还存在免疫细胞、基质细胞等多种细胞。为了适应环境，肿瘤细胞经历了各种物质的代谢重编程。肿瘤细胞的代谢重编程可能进一步影响肿瘤微环境的形成和多种细胞，尤其是免疫细胞的功能，最终促进肿瘤的发展。因此，有必要研究肿瘤细胞的代谢及其对免疫细胞的影响，以指导肿瘤免疫治疗。抑制肿瘤代谢可能恢复免疫平衡，促进肿瘤中的免疫反应。本文将描述肿瘤中的葡萄糖代谢、脂质代谢、氨基酸代谢和免疫细胞，并探讨代谢对 TME 中免疫细胞的影响，以分析和探索肿瘤免疫治疗。
