AP-HP, Hôpital Saint-Antoine, service de Médecine Interne and Inflammation- (DHU i2B), Sorbonnes Université, F-75012, Paris, France.
Obstetrics department, Lille University hospital, CHU, Lille, France.
Eur J Obstet Gynecol Reprod Biol. 2019 May;236:263-264. doi: 10.1016/j.ejogrb.2019.02.036. Epub 2019 Mar 6.
Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.
约 1%至 3%的女性会反复发生早期流产，定义为妊娠 14 周前≥3 次妊娠丢失。免疫失调和耐受破裂可能是这些女性中至少 30%流产的原因。原因不明的慢性绒毛膜炎（CIUE）是一种罕见的胎盘病变，其特征为宫内死亡、生长受限和高复发率。在反复发生产科不良事件和宫内死亡的情况下，我们之前报告了羟氯喹联合泼尼松的益处。尽管很少有数据表明 TNF 拮抗剂在早期复发性流产中的潜在价值，但这些病例显示了其在复发性难治性慢性绒毛膜炎和不明原因流产中的潜在价值。
