Jiangxi Province Tumor Hospital, Nanchang, China.
Surgery Department, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China.
Cancer Lett. 2019 Jun 1;451:150-155. doi: 10.1016/j.canlet.2019.03.001. Epub 2019 Mar 11.
Caspase recruitment domain-containing protein 9 (Card9) is a myeloid cell-specific signaling protein that plays a critical role in NF-κB and MAPK activation. This leads to initiation of the inflammatory cytokine cascade, and elicits the host immune response against microbial invasion, especially in fungal infection. Current research indicates that Card9 plays an important role in tumor progression. Here, we review the data from preclinical and clinical studies of Card9 and suggest the potential for Card9-targeted interventions in the prevention or treatment of certain tumors.
半胱氨酸天冬氨酸蛋白酶募集结构域蛋白 9（Card9）是一种髓样细胞特异性信号蛋白，在 NF-κB 和 MAPK 激活中发挥关键作用。这导致炎症细胞因子级联的启动，并引发宿主对微生物入侵的免疫反应，特别是在真菌感染中。目前的研究表明，Card9 在肿瘤进展中起重要作用。在这里，我们回顾了 Card9 的临床前和临床研究数据，并提出了针对 Card9 的干预措施在预防或治疗某些肿瘤方面的潜力。
