Jiangxi Province Tumor Hospital, Nanchang, China.
Surgery Department, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China.
Cell Death Dis. 2018 Jan 19;9(2):52. doi: 10.1038/s41419-017-0084-6.
CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor allows pattern recognition receptors to induce NF-κB and MAPK activation, which initiates a "downstream" inflammation cytokine cascade and provides effective protection against microbial invasion, especially fungal infection. Here our aim is to update existing paradigms and summarize the most recent findings on the CARD9 signaling pathway, revealing significant mechanistic insights into the pathogenesis of CARD9 deficiency. We also discuss the effect of CARD9 genetic mutations on the in vivo immune response, and highlight clinical advances in non-infection inflammation.
CARD9 是一种包含半胱氨酸天冬氨酸蛋白酶募集结构域的信号蛋白，在先天免疫和适应性免疫中发挥着关键作用。大量研究表明，CARD9 衔接蛋白允许模式识别受体诱导 NF-κB 和 MAPK 的激活，从而引发“下游”炎症细胞因子级联反应，并为对抗微生物入侵（特别是真菌感染）提供有效保护。本综述旨在更新现有的概念模型，总结 CARD9 信号通路的最新研究发现，深入揭示 CARD9 缺陷发病机制的重要机制见解。我们还讨论了 CARD9 基因突变对体内免疫反应的影响，并强调了非感染性炎症的临床进展。
