Department of Physiology, LSU Health Sciences Center, New Orleans, LA 70112, United States of America.
Joint Diabetes, Endocrinology & Metabolism Program, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States of America.
Life Sci. 2019 Apr 15;223:95-101. doi: 10.1016/j.lfs.2019.03.022. Epub 2019 Mar 11.
Individual susceptibility to develop obesity may impact the development of cardio-metabolic risk factors that lead to obesity-related comorbid conditions. Obesity-prone Osborne-Mendel (OM) rats expressed higher levels of visceral adipose inflammation than obesity-resistant, S5B/Pl (S5B) rats. However, the consumption of a high fat diet (HFD) differentially affected OM and S5B rats and induced an increase in visceral adipose inflammation in S5B rats. The current study examined the effects of HFD consumption on cardio-metabolic risk factors in OM and S5B rats.
MATERIALS & METHODS: Glucose regulation and circulating levels of lipids, adiponectin and C-reactive protein were assessed following 8 weeks of HFD or low fat diet (LFD) consumption. Left ventricle hypertrophy and mRNA expression of cardiovascular disease biomarkers were also quantified in OM and S5B rats.
Circulating levels of triglycerides were higher, while HDL cholesterol, adiponectin and glycemic control were lower in OM rats, compared to S5B rats. In the left ventricle, BNP and CTGF mRNA expression were higher in OM rats and IL-6, IL-1β, VEGF, and iNOS mRNA expression were higher in S5B rats.
These findings support the hypothesis that cardio-metabolic risk factors are increased in obesity-prone individuals, which may increase the risk for the development of obesity-related comorbidities. In the current models, obesity-resistant S5B rats also exhibited cardiovascular risk factors supporting the importance of monitoring cardiovascular health in individuals characterized as obesity-resistant.
个体易患肥胖的倾向可能会影响导致肥胖相关合并症的心血管代谢风险因素的发展。与肥胖抵抗的 S5B/Pl（S5B）大鼠相比，肥胖易感的 Osborne-Mendel（OM）大鼠表现出更高水平的内脏脂肪炎症。然而，高脂肪饮食（HFD）的摄入对 OM 和 S5B 大鼠有不同的影响，并导致 S5B 大鼠内脏脂肪炎症增加。本研究探讨了 HFD 摄入对 OM 和 S5B 大鼠心血管代谢风险因素的影响。
在 HFD 或低脂饮食（LFD）摄入 8 周后，评估葡萄糖调节和循环脂质、脂联素和 C 反应蛋白水平。还定量了 OM 和 S5B 大鼠左心室肥大和心血管疾病生物标志物的 mRNA 表达。
与 S5B 大鼠相比，OM 大鼠的循环甘油三酯水平较高，而高密度脂蛋白胆固醇、脂联素和血糖控制水平较低。在左心室中，BNP 和 CTGF mRNA 表达在 OM 大鼠中较高，而 IL-6、IL-1β、VEGF 和 iNOS mRNA 表达在 S5B 大鼠中较高。
这些发现支持这样一种假设，即易患肥胖的个体的心血管代谢风险因素增加，这可能会增加肥胖相关合并症的发展风险。在目前的模型中，肥胖抵抗的 S5B 大鼠也表现出心血管风险因素，这支持了在被认为肥胖抵抗的个体中监测心血管健康的重要性。
