Tryka A F, Witschi H, Gosslee D G, McArthur A H, Clapp N K
Am Rev Respir Dis. 1986 Jun;133(6):1055-9. doi: 10.1164/arrd.1986.133.6.1055.
Do rats, mice, hamsters, and marmosets respond differently to acute lung injury? Animals of each species were exposed to 100% oxygen for 48 h, then osmotic pumps, which released 3H-thymidine for a 1-wk period, were implanted. The labeling index (LI) (cells labeled/total cells counted) was increased in all 4 species. Repair in rats was manifested by a high LI, dominated by endothelial cell proliferation. Mice and hamsters had a lower LI, which was dominated by type II pneumocyte proliferation in mice, whereas in hamsters, macrophages and pneumocytes proliferated. The pattern of cell proliferation in marmosets most resembled that seen in mice.
大鼠、小鼠、仓鼠和狨猴对急性肺损伤的反应是否不同？每个物种的动物均暴露于100%氧气中48小时，然后植入渗透压泵，该泵在1周内释放3H-胸腺嘧啶核苷。所有4个物种的标记指数（LI）（标记细胞数/计数的总细胞数）均升高。大鼠的修复表现为高LI，以内皮细胞增殖为主。小鼠和仓鼠的LI较低，小鼠以II型肺细胞增殖为主，而仓鼠中巨噬细胞和肺细胞增殖。狨猴的细胞增殖模式与小鼠最为相似。
