Wang Zhiqin, Wang Jianfeng, Yi Fang, Zhou Lin, Zhou Yafang
Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Front Hum Neurosci. 2019 Feb 27;13:79. doi: 10.3389/fnhum.2019.00079. eCollection 2019.
Marchiafava-Bignami disease (MBD) is a rare condition characterized by demyelination, necrosis and atrophy of the corpus callosum (CC), and mainly associated with alcoholism. MBD may present with various clinical manifestations. Brain magnetic resonance imaging (MRI) scan is important in prompt diagnosis and treatment of MBD. Here we reported a case of MBD and reviewed literature about the usage of gadolinium-enhanced MRI in MBD. Gadolinium enhancement may indicate a condition at risk of developing necrosis. We therefore recommend a contrast-enhanced MRI study in severe alcoholics with suspected diagnosis of MBD.
马基亚法瓦-比尼亚米病（MBD）是一种罕见病症，其特征为胼胝体（CC）脱髓鞘、坏死和萎缩，主要与酗酒有关。MBD可能有多种临床表现。脑磁共振成像（MRI）扫描对MBD的及时诊断和治疗很重要。在此，我们报告一例MBD病例，并回顾了有关钆增强MRI在MBD中应用的文献。钆增强可能提示有发生坏死的风险。因此，我们建议对疑似诊断为MBD的重度酗酒者进行对比增强MRI研究。
