van Laar Jan A M, Rothova Aniki, Missotten Tom, Kuijpers Robert W A M, van Hagen P Martin, van Velthoven Mirjam E J
Department of Internal Medicine and Immunology, Clinical Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
J Clin Transl Res. 2015 Sep 30;1(2):94-99.
Uveitis is associated with a wide range of underlying causes. Familiarity with its clinical manifestations, referral indications, and treatment strategies are required for the optimal use of current therapeutic options. Uveitis can be caused by infectious and non-infectious factors, resulting in differing prognoses and treatments. The treatment of chronic, non-infectious uveitis has profoundly changed in the last years due to the advent of biologicals, but also of intraocular therapies. In severe uveitis, treatment of the underlying cause, whether ocular or systemic, is required to prevent severe loss of vision. For these purposes, a multidisciplinary clinical approach is important, which is addressed in this review. : A broad understanding of the different causes of uveitis and the implementation of disease-tailored, multidisciplinary management of uveitis is expected to improve treatment outcomes for patients with different types of uveitis.
葡萄膜炎与多种潜在病因相关。为了最佳地利用当前的治疗选择,需要熟悉其临床表现、转诊指征和治疗策略。葡萄膜炎可由感染性和非感染性因素引起,导致不同的预后和治疗方法。由于生物制剂以及眼内治疗方法的出现,慢性非感染性葡萄膜炎的治疗在过去几年发生了深刻变化。在严重的葡萄膜炎中,需要治疗潜在病因,无论病因是眼部的还是全身性的,以防止严重的视力丧失。出于这些目的,多学科临床方法很重要,本综述将对此进行探讨。广泛了解葡萄膜炎的不同病因并实施针对疾病的多学科葡萄膜炎管理,有望改善不同类型葡萄膜炎患者的治疗效果。