Block Janice
Merkaz HaBriut, Center for Integrative Medicine, Ramat Beit Shemesh, Israel.
Kupat Cholim Leumit, Beit Shemesh, Israel.
Homeopathy. 2019 Aug;108(3):214-222. doi: 10.1055/s-0039-1677704. Epub 2019 Mar 14.
The homeopathic materia medica contains hundreds of thousands of observations collected over the course of two centuries. It includes both clinical observations of potentized medicines and observations of the actions of potentized medicines on healthy subjects (provings). This current study was undertaken to determine the degree to which observations within the materia medica were associated with the physiological mechanisms for thyroid activity-inhibiting substances in their undiluted state.
Four specific symptoms for iodine deficiency were selected to describe the hypothyroid state: (1) generalized aggravation by or sensitivity to cold; (2) chronic painless hoarseness; (3) goiter; (4) painless diffuse non-scarring alopecia. Symptom representation for the four selected symptoms within the homeopathic materia medica was compared for 2 halogen inhibitors, for 3 substances that influence thyroid hormone target tissues, for 6 substances known or suspected to increase thyroid-stimulating hormone or decrease thyroid hormone levels, and for 11 substances not known to inhibit thyroid activity. To avoid knowledge bias, only those compilations of materia medica whose publication dates preceded the discoveries of crucial aspects of thyroid physiology were used as source materials for investigation.
Homeopathic medicines derived from 11 substances with mechanisms for inhibition of thyroid activity were more likely to exhibit selected symptoms than the medicines derived from the 11 substances without known physiological mechanisms for thyroid activity inhibition. The difference between groups was analyzed via the Mann-Whitney non-parametric test and was statistically significant to < 0.01. After observations obtained from provings alone were removed from analysis, the difference remained significant to < 0.01. Only the two halogen inhibitors of iodine (bromine and fluoric acid) and one of the influencers of thyroid hormone target tissue (calcium carbonate) were significantly goitrogenic.
With respect to thyroid activity inhibition, there is a statistically significant association between observations recorded within the homeopathic materia medica and the expected physiological mechanisms for the corresponding undiluted substances.
顺势疗法药物学包含了两个世纪以来收集的数十万条观察结果。它既包括对药力增强药物的临床观察，也包括对药力增强药物作用于健康受试者（药效验证）的观察。本研究旨在确定药物学中的观察结果与未稀释状态下甲状腺活性抑制物质的生理机制之间的关联程度。
选择碘缺乏的四种特定症状来描述甲状腺功能减退状态：（1）对寒冷普遍加重或敏感；（2）慢性无痛性声音嘶哑；（3）甲状腺肿；（4）无痛性弥漫性非瘢痕性脱发。比较了顺势疗法药物学中所选四种症状在2种卤素抑制剂、3种影响甲状腺激素靶组织的物质、6种已知或疑似增加促甲状腺激素或降低甲状腺激素水平的物质以及11种未知抑制甲状腺活性的物质中的症状表现。为避免知识偏差，仅将那些出版日期早于甲状腺生理学关键方面发现的药物学汇编用作调查的源材料。
源自11种具有甲状腺活性抑制机制的物质的顺势疗法药物比源自11种无已知甲状腺活性抑制生理机制的物质的药物更有可能表现出所选症状。通过曼-惠特尼非参数检验分析组间差异，差异具有统计学意义（P<0.01）。仅从验证中获得的观察结果从分析中剔除后，差异仍然具有统计学意义（P<0.01）。只有两种碘的卤素抑制剂（溴和氟酸）以及一种甲状腺激素靶组织的影响物质（碳酸钙）具有显著的致甲状腺肿作用。
关于甲状腺活性抑制，顺势疗法药物学中记录的观察结果与相应未稀释物质的预期生理机制之间存在统计学上的显著关联。
