Cannizzaro G, Brucato A F, Provenzano P M
Arzneimittelforschung. 1986 Apr;36(4):718-21.
The action of single and repeated treatment with chlordiazepoxide (CDP) (5-10 mg/kg i.p.) and sodium valproate (VPA) (100-200 mg/kg i.p.) on water intake of rats adapted to a daily 23-h water deprivation schedule was investigated. The influence exerted by single or repeated treatment of the two drugs on the antidipsogenic effect of naloxone (Nx) (1 mg/kg s.c.) was studied too. Our results show that with single treatment of CDP the dipsogenic effect is lower and not further modified by increasing dose and by the time-course of the session; with repeated treatment the dipsogenic effect is greater and further enhanced by increasing dose and by the time-course of the session. Single or repeated treatment with VPA does not significantly affect the water intake. Single treatment of CDP enhances the antidipsogenic effect of Nx, while CDP, after repeated treatment, reverses the antidipsogenic effect of Nx. With VPA-Nx association, the response is univocal (antidipsogenic effect) independent of the experimental conditions. The results are briefly discussed.
研究了单次及重复给予氯氮卓（CDP）（腹腔注射5 - 10毫克/千克）和丙戊酸钠（VPA）（腹腔注射100 - 200毫克/千克）对适应每日23小时禁水方案的大鼠饮水量的影响。还研究了这两种药物单次或重复给药对纳洛酮（Nx）（皮下注射1毫克/千克）抗饮水作用的影响。我们的结果表明，单次给予CDP时，饮水诱导作用较低，且增加剂量和给药时间过程不会进一步改变该作用；重复给药时，饮水诱导作用更大，且增加剂量和给药时间过程会进一步增强该作用。单次或重复给予VPA对饮水量无显著影响。单次给予CDP可增强Nx的抗饮水作用，而重复给药后，CDP会逆转Nx的抗饮水作用。对于VPA - Nx联合用药，无论实验条件如何，反应都是单一的（抗饮水作用）。对结果进行了简要讨论。
