Cannizzaro G, Flugy A, Novara V, Provenzano P M
Arzneimittelforschung. 1987 Jan;37(1):6-9.
The effects of chlordiazepoxide (CDP, 5 mg/kg i.p.), the sodium salt of valproic acid (VPA, 200 mg/kg i.p.) and naloxone (Nx, 1 mg/kg s.c.) alone and CDP-Nx, VPA-Nx association on schedule controlled behaviour with signalled unpunished and punished periods, were investigated. Our results show that CDP and VPA under both the unemotional (variable ratio reinforcement schedule 20%) and the emotional (continuous reinforced schedule associated with electric shock) components significantly increase responding in the Skinner box. Nx, on the multiple schedule, non-significantly reduces responding under both components. With CDP-Nx association the increase in responding under the unemotional component is less than in the case of the benzodiazepine alone, while under the emotional component the increase in responding is not appreciably affected. With the VPA-Nx association the responding rate is lower than that of the control under the unemotional component while under the emotional component the increase in responding is reduced compared to the VPA alone. The higher rates of unemotional and emotional responding with both CDP and VPA depend on the dipsogenic and disinhibiting effects by both drugs. The different rate of emotional and unemotional responding with CDP-Nx and VPA-Nx associations indicates a specific influence on GABAergic and other systems by CDP and VPA.
研究了单独使用氯氮卓（CDP，腹腔注射5mg/kg）、丙戊酸钠（VPA，腹腔注射200mg/kg）和纳洛酮（Nx，皮下注射1mg/kg）以及CDP与Nx、VPA与Nx联合使用对有信号提示的无惩罚期和惩罚期的定时控制行为的影响。我们的结果表明，在非情绪化（可变比率强化程序20%）和情绪化（与电击相关的连续强化程序）两种情况下，CDP和VPA均显著增加了斯金纳箱中的反应。在多重程序中，Nx对两种情况下的反应均有非显著降低。CDP与Nx联合使用时，非情绪化成分下反应的增加小于单独使用苯二氮卓类药物的情况，而在情绪化成分下，反应的增加没有明显受到影响。VPA与Nx联合使用时，非情绪化成分下的反应率低于对照组，而在情绪化成分下，与单独使用VPA相比，反应的增加有所减少。CDP和VPA在非情绪化和情绪化反应中的较高比率取决于两种药物的致渴和去抑制作用。CDP与Nx、VPA与Nx联合使用时在情绪化和非情绪化反应中的不同比率表明CDP和VPA对GABA能系统和其他系统有特定影响。
