联合蒙特卡罗和光动力模拟方法验证对小鼠血啉甲醚介导光动力治疗效果的相关性分析。
Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice.
机构信息
Simphotek, Inc., Newark, New Jersey, United States.
University of Pennsylvania, Department of Radiation Oncology, Philadelphia, Pennsylvania, United States.
出版信息
J Biomed Opt. 2019 Mar;24(3):1-9. doi: 10.1117/1.JBO.24.3.035006.
Abstract
We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosie™, that calculates light transport and photokinetics for PDT in near real-time. The two sets of results are consistent and validate the use of the device in PDT treatment planning to predict BPD-mediated PDT outcomes in mice animal studies based on singlet oxygen dose, which showed a much better correlation with the cure index than the conventional light dose.
摘要
我们将先前报道的苯并卟啉衍生物（BPD）介导的光动力疗法（PDT）结果与使用计算设备 Dosie™进行的模拟进行比较，该设备可实时计算 PDT 的光传输和光动力学。这两组结果是一致的，验证了该设备在 PDT 治疗计划中的使用，可根据单线态氧剂量预测小鼠动物研究中 BPD 介导的 PDT 结果，与传统光剂量相比，它与治愈率的相关性要好得多。
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