a Department of Chemical Engineering , American University of Sharjah , Sharjah , UAE.
b Department of Biology, Chemistry and Environmental Sciences , American University of Sharjah , Sharjah , UAE.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):705-714. doi: 10.1080/21691401.2019.1573175.
Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumour site. Once at the tumour site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal formulation with ultrasonic triggering techniques, promises a safe, effective and site-specific breast cancer therapy.
靶向脂质体在将其负载的治疗剂特异性和有效地递送到肿瘤部位方面具有很大的潜力。一旦到达肿瘤部位，重要的是这些脂质体被触发以可控和有效的方式释放其负载。在这项研究中，研究了与人血清白蛋白（HSA）缀合的聚乙二醇化（隐形）脂质体用于递送模型药物（钙黄绿素）至乳腺癌细胞。荧光结果表明，与非靶向对照脂质体相比，两种乳腺癌细胞系（MDA-MB-231 和 MCF-7）对 HSA-PEG 脂质体的钙黄绿素摄取明显更高。此外，与没有超声的摄取相比，低频超声（LFUS）的暴露导致钙黄绿素摄取的统计学显著增加。所描述的药物递送（DD）系统，涉及将靶向脂质体制剂与超声触发技术相结合，有望实现安全、有效和靶向的乳腺癌治疗。
