Levy Michael, Barletta Scott, Huang Hwa, Grossman Stuart A, Rodriguez Fausto J, Ellsworth Susannah G, Dzaye Omar, Holdhoff Matthias
a Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.
b Department of Neurology , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.
Cancer Invest. 2019;37(2):67-72. doi: 10.1080/07357907.2018.1564927. Epub 2019 Mar 15.
There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus inactive GBM) between baseline and time of repeat biopsy. In addition, there was no clear relationship between AQP4 expression and degree of edema.
水通道蛋白4（AQP4）在胶质母细胞瘤（GBM）中的存在及其潜在作用一直存在争议。我们分析了22例新诊断GBM患者的组织，以及其中17例因疑似复发而接受再次切除的患者的匹配组织，并对AQP-4表达进行了免疫组织化学分析。虽然在所有22例（39份样本）中均检测到一定程度的AQP4表达，但基线和再次活检时的染色模式与疾病状态（活跃性与非活跃性GBM）之间没有明确的关系。此外，AQP4表达与水肿程度之间也没有明确的关系。
