组织蛋白酶G及其在炎症和自身免疫性疾病中的作用。
Cathepsin G and Its Role in Inflammation and Autoimmune Diseases.
作者信息
Gao Siming, Zhu Honglin, Zuo Xiaoxia, Luo Hui
机构信息
Department of Rheumatology, Xiangya Hospital, Hunan, China.
出版信息
Arch Rheumatol. 2018 Jan 22;33(4):498-504. doi: 10.5606/ArchRheumatol.2018.6595. eCollection 2018 Dec.
Abstract
Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases. In this article, we discuss the roles of cathepsin G in inflammation, immune reaction, and autoimmune diseases. To our knowledge, this is the first study providing important information about cathepsin G in the pathogenesis of autoimmune diseases and suggesting that cathepsin G may be a new biomarker or treatment target.
摘要
组织蛋白酶G属于中性粒细胞丝氨酸蛋白酶家族，以其在杀灭病原体中的作用而闻名。过去几年的研究表明，组织蛋白酶G对炎症和免疫反应具有重要影响，可能是某些自身免疫性疾病发病机制中的关键因素。在本文中，我们讨论了组织蛋白酶G在炎症、免疫反应和自身免疫性疾病中的作用。据我们所知，这是第一项提供有关组织蛋白酶G在自身免疫性疾病发病机制中的重要信息并表明组织蛋白酶G可能是一种新的生物标志物或治疗靶点的研究。
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