Valentini G, Chianese U, Tirri G, Giordano M
Z Rheumatol. 1978 Jul-Aug;37(7-8):233-41.
A platelet count was made in 37 patients with Progressive Systemic Sclerosis (PSS), 6 with Sjögren's Syndrome, 11 with Rheumatic Polymyalgia with or without Horton's Arteritis (PMR-AH), 26 with Ankylosing Spondylitis (A.Sp.), 29 with Psoriatic Arthritis, 15 with Gout and in 65 healthy subjects. In this last group the mean platelet count was 215.692/mm3, S.E. 4.167. In the various groups of patients the following mean platelet counts were determined: PSS 242.108 +/- 11.766; Sjögren 245.000 +/- 22.620; PMR-AH 276.818 +/- 25.577; A.Sp. 272.846 +/- 14.124; Psoriatic Arthritis 245.833 +/- 9.374; Gout 265.333 +/- 24.628. Statistical analysis showed a significant difference (P less than 0.05), (P less than 0.01) or (P less than 0.001) between each group of patients and the controls. However, the platelet count in the majority of patients in each group was not higher than 300.000/mm3. Statistically significant correlations were found between platelet count and some biolgoical inflammation parameters. All patients with platelets higher than 300.000/mm3 showed a high disease activity. Yet some patients with marked inflammation did not present thrombocytosis. According to literature data thrombocytosis in Rheumatoid Arthritis is considered to be correlated to disease activity. The results of this study indicate that even in other rheumatic diseases thrombocytosis is often present, apparently correlated to the inflammation. Therefore thrombocytosis is an inflammation parameter; but it is less sensitive than other ones.
对37例进行性系统性硬化症（PSS）患者、6例干燥综合征患者、11例伴有或不伴有 Horton 动脉炎的风湿性多肌痛（PMR-AH）患者、26例强直性脊柱炎（A.Sp.）患者、29例银屑病关节炎患者、15例痛风患者以及65名健康受试者进行了血小板计数。在最后一组健康受试者中，平均血小板计数为215.692/mm³，标准误为4.167。在各患者组中，测定的平均血小板计数如下：PSS为242.108±11.766；干燥综合征为245.000±22.620；PMR-AH为276.818±25.577；A.Sp.为272.846±14.124；银屑病关节炎为245.833±9.374；痛风为265.333±24.628。统计分析表明，每组患者与对照组之间存在显著差异（P＜0.05）、（P＜0.01）或（P＜0.001）。然而，每组中大多数患者的血小板计数不高于300,000/mm³。在血小板计数与一些生物学炎症参数之间发现了具有统计学意义的相关性。所有血小板高于300,000/mm³的患者疾病活动度较高。然而，一些炎症明显的患者并未出现血小板增多症。根据文献数据，类风湿关节炎中的血小板增多症被认为与疾病活动度相关。本研究结果表明，即使在其他风湿性疾病中也经常出现血小板增多症，显然与炎症相关。因此，血小板增多症是一个炎症参数；但它比其他参数敏感性更低。
