Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos, SP, Brazil.
Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Santos, SP, Brazil.
Inflamm Res. 2019 May;68(5):359-368. doi: 10.1007/s00011-019-01223-1. Epub 2019 Mar 14.
The present study aimed to evaluate and clarify how the age at which the intake of a high-fat and high-fructose diet begins can affect animals' livers.
Thirty-eight male wistar rats aged 6 and 12 weeks were fed a high-fat and high-fructose diet for 13 weeks. Inflammatory cytokines, hepatic glycogen, serum and hepatic triacylglycerol and pAkt protein content in the liver were assessed. Percentage of weight gained, and visceral adiposity were also evaluated.
Young animal presented increased hepatic triacylglycerol and decreased glycogen, while adult animals had no significant alterations regarding its contents. IL6 and IL10 to IL6 ratio were also altered in young animals exposed to HFHF, while adult animals fed with HFHF had only increases in TNF-α. Both groups which received HFHF had increased serum triacylglycerol and visceral adiposity. However, only young animals gained more relative weight and had greater final body weight, gains which were related to alterations found in hepatic triacylglycerol and glycogen.
Age of which consumption begins interferes in how the liver deals with an excess of nutrient and subsequent proinflammatory stimulation, leading to different phenotypes.
本研究旨在评估和阐明高脂肪高果糖饮食开始摄入的年龄如何影响动物的肝脏。
38 只 6 周和 12 周龄雄性 wistar 大鼠给予高脂肪高果糖饮食 13 周。评估炎症细胞因子、肝糖原、血清和肝三酰甘油以及肝组织中 pAkt 蛋白含量。还评估体重增加百分比和内脏脂肪。
年轻动物的肝三酰甘油增加，糖原减少，而成年动物的肝组织中这些物质的含量没有明显变化。暴露于 HFHF 的年轻动物的 IL6 和 IL10 与 IL6 的比值也发生了改变，而给予 HFHF 的成年动物仅 TNF-α 增加。两组 HFHF 喂养的动物血清三酰甘油和内脏脂肪均增加。然而，只有年轻动物增加了相对体重，且最终体重增加更多，这些增加与肝组织中三酰甘油和糖原的变化有关。
开始摄入的年龄会影响肝脏对过量营养和随后的促炎刺激的处理方式，导致不同的表型。
