Morozov V G, Khavinson V Kh, Il'in N V
Zh Mikrobiol Epidemiol Immunobiol. 1978 Jul(7):61-5.
Lowmolecular factor of polypeptide nature (thymarin) was extracted from calf thymus. This factor differed by physical and chemical characteristics from thymosin. The percentage content of "active" T-lymphocytes increased under the effect of thymarin in the cultures of lymphoid cells obtained from healthy individuals. The total T-cell count remained unchanged. Thymarin favoured increase of the total T-lymphocyte and "active" T-lymphocyte count in the cultures of cells from patients with chronic inflammatory processes. Cellular immunity reactions were restored and the course of the main disease improved under the effect of parenteral administration of thymarin. It is supposed that T-immunity system incompetence was associated with the inadequate production of the thymus factor capable of restoring the activity of the thymus-dependent lymphocyte population.
从小牛胸腺中提取了具有多肽性质的低分子因子（胸腺素）。该因子在物理和化学特性上与胸腺肽不同。在胸腺素的作用下，从健康个体获得的淋巴细胞培养物中“活性”T淋巴细胞的百分比含量增加。T细胞总数保持不变。胸腺素有利于慢性炎症患者细胞培养物中总T淋巴细胞和“活性”T淋巴细胞数量的增加。在胸腺素胃肠外给药的作用下，细胞免疫反应得以恢复，主要疾病的病程得到改善。据推测，T免疫系统功能不全与能够恢复胸腺依赖性淋巴细胞群体活性的胸腺因子产生不足有关。
