Kosmiadi G A, Grigor'eva M P, Korotaev G K, Il'intseva I E, Grigor'ev M Iu
Vopr Onkol. 1979;25(10):7-11.
The activity of thymosin obtained from calf thymus was examined in the tests in vitro: the reaction of spontaneous rosette formation, blasttransformation reaction to PHA and the reaction of leucocyte migration inhibition. It was demonstrated that the activity which stimulates T-lymphocytes would appear only in cases where donor lymphocytes show depletion in terms of rosette formation and blasttransformation. In some patients thymosin was found to produce the in vitro activation of cell anti-tumor immunity.
自然花环形成反应、对PHA的母细胞转化反应以及白细胞游走抑制反应。结果表明,刺激T淋巴细胞的活性仅在供体淋巴细胞在花环形成和母细胞转化方面表现出耗竭的情况下才会出现。在一些患者中,发现胸腺素可在体外激活细胞抗肿瘤免疫。