源自一名散发性帕金森病患者的人诱导多能干细胞（iPSC）系（HEBHMUi001-A）的建立与鉴定
Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient.
作者信息
Ma Jun, Guo Ruiyun, Song Yongzhou, Zhang Jing, Feng Baofeng, Amponsah Asiamah Ernest, Kong Desheng, He Jingjing, Zhang Wei, Liu Aijing, Wei Lin, Shen Sanbing, O'Brien Timothy, Cui Huixian
机构信息
Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China.
Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China.
出版信息
Stem Cell Res. 2019 Apr;36:101417. doi: 10.1016/j.scr.2019.101417. Epub 2019 Mar 7.
We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.
我们从一名临床诊断为散发性帕金森病（PD）的62岁女性患者的皮肤成纤维细胞中生成了一条人诱导多能干细胞（iPSC）系。所生成的iPSC保持其正常核型，表达多能干细胞标志物，并被证明能够分化为代表三个胚胎胚层的细胞。所生成的细胞系可用于帕金森病建模，以了解影响该疾病的机制。
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