Department of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
Institute for Digestive Research, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
Int J Mol Sci. 2019 Mar 14;20(6):1277. doi: 10.3390/ijms20061277.
Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the and genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between variant and variant and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the risk variant for the development of hepatic fibrosis and liver cirrhosis. The study was conducted at the Department of Gastroenterology, Lithuanian University of Health Sciences Hospital, and included 334 patients with liver cirrhosis, 128 patients with liver fibrosis, and 550 controls. SNPs were genotyped by quantitative PCR, using TaqMan allelic discrimination assays. Overall, as well as were not linked to hepatic fibrosis, alcohol or hepatitis C virus induced liver cirrhosis in an Eastern European population. These genetic variations also did not mediate the effect of SNP for liver developing liver fibrosis or liver cirrhosis.
先前的大规模遗传研究确定了 和 基因的单核苷酸多态性 (SNPs) 是酒精性肝硬化和非酒精性脂肪性肝病的风险因素。在这项研究中，我们试图评估 变体和 变体与不同病因的肝纤维化或肝硬化风险之间的关联。同时，我们还旨在评估这两个 SNPs 是否会改变 风险变异对肝纤维化和肝硬化发展的影响。该研究在立陶宛健康科学大学医院的胃肠病学系进行，共纳入 334 例肝硬化患者、128 例肝纤维化患者和 550 名对照。通过定量 PCR 使用 TaqMan 等位基因区分测定法对 SNPs 进行基因分型。总的来说，在东欧人群中， 以及 与肝纤维化、酒精或丙型肝炎病毒引起的肝硬化无关。这些遗传变异也不会介导 SNP 对肝脏发生肝纤维化或肝硬化的影响。
