Orr W B, Gardiner T W, Stricker E M, Zigmond M J, Berger T W
Brain Res. 1986 Jun 18;376(1):20-8. doi: 10.1016/0006-8993(86)90895-4.
The spontaneous activity of striatal neurons was measured after dopamine (DA)-depleting brain lesions were produced in rats by the neurotoxin 6-hydroxydopamine. The extent of DA depletion was determined using tissue punches from the same regions of striatum in which cell activity was recorded. Results showed that the spontaneous activity of Type II neurons in either the medial or lateral striatum increased only when local DA depletions exceeded 90%; when local depletions were less than 90%, spontaneous firing rates of Type II neurons were equivalent to control values. This finding was consistent with additional observations that ingestive and motor behaviors of the same animals were not disrupted until striatal DA depletions exceeded 90%. It also was found that spontaneous firing rates of neurons in the lateral but not the medial striatum could be at control levels in animals clearly exhibiting aphagia, adipsia and akinesia.
通过神经毒素6-羟基多巴胺对大鼠造成多巴胺（DA）耗竭性脑损伤后，对纹状体神经元的自发活动进行了测量。使用来自记录细胞活动的纹状体相同区域的组织块来确定DA耗竭的程度。结果表明，仅当内侧或外侧纹状体局部DA耗竭超过90%时，II型神经元的自发活动才会增加；当局部耗竭低于90%时，II型神经元的自发放电率与对照值相当。这一发现与其他观察结果一致，即相同动物的摄食和运动行为直到纹状体DA耗竭超过90%才会受到干扰。还发现，在明显表现出摄食不能、饮水不能和运动不能的动物中，外侧纹状体而非内侧纹状体神经元的自发放电率可以处于对照水平。
