Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Guangxi Collaborative Innovation Center for Biomedicine, Life Sciences Institute, Guangxi Medical University, Nanning, 530021, Guangxi, China.
AIDS Res Ther. 2019 Mar 16;16(1):6. doi: 10.1186/s12981-019-0221-7.
This study aimed to investigate the prevalence of HIV late presentation and advanced HIV disease and to identify the factors associated with HIV late presentation and advanced HIV disease among patients with newly diagnosed HIV/AIDS in the Guangxi Zhuang Autonomous Region, in Southwestern China.
Patients with newly diagnosed HIV registered in the HIV surveillance system of Guangxi Centers for Disease Control between January 2012 and December 2016 were included in this study.
Of 45,118 newly diagnosed patients, 70.2% had late presentation, and 45.1% had advanced HIV disease. A higher prevalence of late presentation and advanced HIV disease was found in male heterosexuals and female people who use drugs (PWID). Heterosexuals (OR 2.11 [95% CI 1.90-2.34]) and PWID (OR 1.55 [95% CI 1.30-1.84]) had a higher risk of late presentation than men who have sex with men (MSM). Blood testing of the blood receivers (OR 1.75 [95% CI 1.36-2.26]) and diagnosed in hospital (OR 1.74 [95% CI 1.65-1.84]) had an increased risk of late presentation compared to those who diagnosis in voluntary counseling and testing (VCT). Heterosexuals (OR 2.86 [95% CI 2.51-3.27]), PWID (OR 2.23 [95% CI 1.83-2.71]), blood testing of the blood receivers (OR 1.58 [95% CI 1.29-1.94]) and diagnosed in hospital (OR 1.85 [95% CI 1.76-1.94]) were also independent risk factors associated with advanced HIV disease. Older age, lower level of education and being divorced or widowed were also associated with late presentation and advanced HIV disease.
Late presentation and advanced HIV disease were very common among patients with newly diagnosed HIV in Guangxi, China during 2012-2016. Targeted programs are urgently required to reduce HIV late diagnosis in Guangxi, especially for male heterosexuals, PWID, and patients with characteristics such as older age, lower level of education, divorced or widowed.
本研究旨在调查中国广西新诊断 HIV/AIDS 患者中 HIV 晚期表现和艾滋病晚期的流行情况，并确定与 HIV 晚期表现和艾滋病晚期相关的因素。
本研究纳入了 2012 年 1 月至 2016 年 12 月期间在广西疾病预防控制中心 HIV 监测系统中登记的新诊断 HIV 患者。
在 45118 名新诊断患者中，70.2%为 HIV 晚期表现，45.1%为艾滋病晚期。男性异性恋者和女性吸毒者（PWID）的 HIV 晚期表现和艾滋病晚期患病率较高。异性恋者（OR 2.11[95%CI 1.90-2.34]）和 PWID（OR 1.55[95%CI 1.30-1.84]）与男男性接触者（MSM）相比，HIV 晚期表现的风险更高。与自愿咨询检测（VCT）相比，血液检测的供血者（OR 1.75[95%CI 1.36-2.26]）和医院诊断（OR 1.74[95%CI 1.65-1.84]）增加了 HIV 晚期表现的风险。异性恋者（OR 2.86[95%CI 2.51-3.27]）、PWID（OR 2.23[95%CI 1.83-2.71]）、血液检测的供血者（OR 1.58[95%CI 1.29-1.94]）和医院诊断（OR 1.85[95%CI 1.76-1.94]）也是艾滋病晚期的独立危险因素。年龄较大、受教育程度较低以及离异或丧偶也是 HIV 晚期表现和艾滋病晚期的相关因素。
2012-2016 年期间，广西新诊断 HIV 患者中 HIV 晚期表现和艾滋病晚期非常普遍。急需开展针对性项目，减少广西 HIV 晚期诊断，特别是减少男性异性恋者、PWID 以及年龄较大、受教育程度较低、离异或丧偶等特征的患者的 HIV 晚期诊断。
