Kutkienė Sandra, Petrulionienė Žaneta, Laucevičius Aleksandras, Čerkauskienė Rimantė, Samuilis Artūras, Augaitienė Virginija, Gedminaitė Aurelija, Bieliauskienė Gintarė, Šaulytė-Mikulskienė Akvilė, Staigytė Justina, Petrulionytė Emilija, Gargalskaitė Urtė, Skiauterytė Eglė, Matuzevičienė Gabija, Kovaitė Milda, Nedzelskienė Irena
Vilnius University, Faculty of Medicine, Clinic of Cardiac and Vascular Diseases, Lithuania; Vilnius University, Faculty of Medicine, Lithuania; Vilnius University Hospital Santaros Klinikos, Lithuania.
Vilnius University, Faculty of Medicine, Clinic of Cardiac and Vascular Diseases, Lithuania; Vilnius University, Faculty of Medicine, Lithuania; Vilnius University Hospital Santaros Klinikos, Lithuania.
Atheroscler Suppl. 2019 Mar;36:6-11. doi: 10.1016/j.atherosclerosissup.2019.01.002. Epub 2019 Jan 29.
Achilles tendon lesions have long been associated with genetic defects in lipid metabolism and increased risk of cardiovascular diseases (CVD). With this study we aimed to evaluate the usefulness of Achilles tendon ultrasonography in identifying people at greater risk among subjects with severe hypercholesterolemia (SH) in a high-risk population.
During the period of 2016-2017 a total of 213 participants were enrolled in this case-control study. Data of 110 patients with SH and 103 age and sex matched controls without dyslipidaeplemia and established CVD was collected.
Achilles tendinopathy (AT) was present in 42.7% of subjects with SH and in 29.1% of controls (p = 0.039). Stronger association between SH and AT was seen in women - 24.1% vs 2.0% (p = 0.001). SH increased odds of AT by 1.815 (95% CI, 1.028-3.206). Prevalence of AT was higher in males despite presence (SH) or absence (SH) of severe hypercholesterolemia (SH 60.7% vs 24.1%, SH 55.8% vs 2.0%, p < 0.001). AT was associated with higher proportion of subjects exceeding normal mean values of TC (80.5% vs 52.9%, p = 0.001), LDL-C (76.6% vs 52.2%), TG (54.5% vs. 22.1%), ApoB (57.1% vs 22.2%), ApoE (44.0% vs 22.4%) levels and ApoB/ApoA ratio (46.1% vs 21.5%) (p = 0.001) and family history of premature coronary heart disease (CHD).
AT is more prevalent among subjects with SH and is associated with higher levels of TC, TG, LDL-C, ApoB, ApoE, ApoB/ApoA ratio, family history of premature CHD. SH increases the odds of developing AT.
跟腱损伤长期以来一直与脂质代谢的基因缺陷以及心血管疾病（CVD）风险增加相关。通过本研究，我们旨在评估跟腱超声检查在识别高危人群中重度高胆固醇血症（SH）患者中更高风险人群方面的实用性。
在2016 - 2017年期间，共有213名参与者纳入了这项病例对照研究。收集了110例SH患者以及103例年龄和性别匹配、无血脂异常和确诊CVD的对照者的数据。
SH患者中42.7%存在跟腱病（AT），对照组中这一比例为29.1%（p = 0.039）。女性中SH与AT的关联更强——24.1% 对比2.0%（p = 0.001）。SH使AT的患病几率增加了1.815（95%可信区间，1.028 - 3.206）。无论是否存在重度高胆固醇血症（SH），男性中AT的患病率均较高（SH组为60.7%对比24.1%，非SH组为55.8%对比2.0%，p < 0.001）。AT与超过总胆固醇（TC）正常均值（80.5%对比52.9%，p = 0.001）、低密度脂蛋白胆固醇（LDL-C）（76.6%对比52.2%）、甘油三酯（TG）（54.5%对比22.1%）、载脂蛋白B（ApoB）（57.1%对比22.2%）、载脂蛋白E（ApoE）（44.0%对比22.4%）水平以及ApoB/ApoA比值（46.1%对比21.5%）（p = 0.001）的受试者比例更高以及早发冠心病（CHD）家族史相关。
AT在SH患者中更为普遍，并且与更高水平的TC、TG、LDL-C、ApoB、ApoE、ApoB/ApoA比值以及早发CHD家族史相关。SH增加了发生AT的几率。
