School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
Med Sci Sports Exerc. 2009 Jun;41(6):1194-7. doi: 10.1249/MSS.0b013e31819794c3.
Overuse is considered to be a main causative factor for tendinopathies; however, recent reports indicate that tendinopathy is also common among both overweight and inactive individuals. These factors are associated with abdominal obesity, dyslipidemia, hypertension, and insulin resistance. We hypothesized that these features would be associated with tendinopathy.
To compare lipid profile between participants with Achilles tendinopathy and matched controls.
Fasting serum lipids were measured among 60 participants with chronic painful midportion Achilles tendinopathy (54% male) and 60 control subjects matched for gender, age (+/-10 yr), and body mass index (+/-2 kg x m(-2)).
The participants with Achilles tendinopathy showed evidence of underlying dyslipidemia. They had higher triglyceride (TG) levels (P = 0.039), lower %HDL-C (P = 0.016), higher TG/HDL-C ratio (P = 0.036), and elevated apolipoprotein B concentration (P = 0.017) in comparison to the well-matched control group.
This pattern of dyslipidemia is characteristic of the dyslipidemia displayed by individuals with insulin resistance and is common in the metabolic syndrome. Two additional aspects of tendinopathy research support a connection with the metabolic syndrome. First, tendinopathy has been associated with greater waist circumference, as has the metabolic syndrome. Second, insulin resistance has been associated with fat deposition in muscle (primarily intracellular), whereas fat deposition in tendon has been found among those with tendon pain.If tendinopathy is confirmed to be associated with dyslipidemia and the metabolic syndrome in larger studies, it may be appropriate to redefine our concept of tendinopathy to that of a cardiovascular disease (CVD). In this case, we may be able to draw considerably on CVD research to improve our understanding of tendinopathy, and perhaps treating CVD risk factors will improve the treatment of tendinopathy.
过度使用被认为是导致腱病的主要因素；然而，最近的报告表明，超重和不活跃的人也容易患腱病。这些因素与腹部肥胖、血脂异常、高血压和胰岛素抵抗有关。我们假设这些特征与腱病有关。
比较跟腱病患者和匹配对照组之间的血脂谱。
对 60 名患有慢性疼痛中段跟腱病的患者（54%为男性）和 60 名性别、年龄（相差 10 岁）和体重指数（相差 2kg/m²）相匹配的对照组进行空腹血清脂质检测。
跟腱病患者存在潜在的血脂异常。他们的甘油三酯（TG）水平较高（P = 0.039），高密度脂蛋白胆固醇（HDL-C）百分比较低（P = 0.016），TG/HDL-C 比值较高（P = 0.036），载脂蛋白 B 浓度升高（P = 0.017），与相匹配的对照组相比。
这种血脂异常模式是胰岛素抵抗患者血脂异常的特征，在代谢综合征中很常见。腱病研究的另外两个方面支持与代谢综合征的联系。首先，腱病与更大的腰围有关，代谢综合征也是如此。其次，胰岛素抵抗与肌肉（主要是细胞内）脂肪沉积有关，而在有肌腱疼痛的人群中发现了肌腱中的脂肪沉积。如果在更大的研究中证实腱病与血脂异常和代谢综合征有关，那么我们可能需要重新定义腱病的概念，将其定义为心血管疾病（CVD）。在这种情况下，我们可以从 CVD 研究中汲取大量知识来加深我们对腱病的理解，也许治疗 CVD 风险因素将改善腱病的治疗。
