Arai T, Tsukahara I, Nitta K, Watanabe T
Crit Care Med. 1986 Jul;14(7):634-7. doi: 10.1097/00003246-198607000-00010.
The effects of hypertonic mannitol on postischemic cerebral circulation were studied in 20 dogs. Mannitol, 2 g/kg iv, was infused into ten dogs during a 2-h period starting 1.5 h after 6 min of complete cerebral ischemia. One hour postischemia, regional cerebral blood flow (rCBF) was 36% in the control group (ten dogs) and 39% in the mannitol group. In the control group, rCBF increased gradually thereafter to 70% of the preischemic value 10 h postischemia, whereas the restoration of rCBF was suppressed in the mannitol group. During the postischemic period, intracranial pressure (ICP) increased significantly in the control group, but it did not change significantly in the mannitol group. The effects of mannitol on rCBF and ICP in the present study can be explained primarily by decreased body water due to urinary loss. The administration of mannitol does not necessarily improve postischemic cerebral circulation.
在20只犬中研究了高渗甘露醇对缺血后脑循环的影响。在20只犬经历6分钟完全性脑缺血后1.5小时开始的2小时内，给10只犬静脉输注2 g/kg的甘露醇。缺血1小时后，对照组（10只犬）的局部脑血流量（rCBF）为36%，甘露醇组为39%。在对照组中，此后rCBF逐渐增加，缺血10小时后恢复至缺血前值的70%，而甘露醇组rCBF的恢复受到抑制。在缺血后期间，对照组颅内压（ICP）显著升高，但甘露醇组无明显变化。本研究中甘露醇对rCBF和ICP的影响主要可通过因尿流失导致的机体水分减少来解释。给予甘露醇不一定能改善缺血后脑循环。
