药物递送至视网膜光感受器。

InoCure s.r.o., Prague, Czech Republic.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Ophthalmology, Lund, Sweden.

Drug Discov Today. 2019 Aug;24(8):1637-1643. doi: 10.1016/j.drudis.2019.03.004. Epub 2019 Mar 13.

The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood-retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.

视网膜的感光细胞易患一些疾病，而这些疾病的治疗方法往往仍不尽如人意。尽管在某些情况下可能有合适的药物，但这些化合物进入眼睛并穿过血视网膜屏障仍然是治疗开发的一个重大挑战。在这里，我们回顾了药物向视网膜的给药途径，并强调了向光感受器细胞给药的不同选择。