Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong.
Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong.
Drug Discov Today. 2019 Aug;24(8):1510-1523. doi: 10.1016/j.drudis.2019.05.005. Epub 2019 May 16.
Intravitreal injection is one of the major administration routes for the treatment of posterior ocular diseases. Intravitreal therapeutics usually suffer from unsatisfactory efficacy owing to fast clearance from the vitreous humour and insufficient distribution into the retina. Engineered nanoparticles have been applied for specific tissue targeting over the past decades. In this review, we summarize the most recent research utilizing intravitreal nanoparticles to deliver therapeutics to the retina. Herein, the achievement made in preclinical research and challenges remaining in the field are highlighted. Parameters including size, charge, stability and choice of modified ligand on intraocular distribution and transport are also systematically discussed based on a proposed pharmacokinetic model. We provide insights for rational design principles for intravitreal nanoparticles for targeted retinal delivery.
玻璃体腔内注射是治疗眼后段疾病的主要给药途径之一。由于玻璃体清除快和向视网膜分布不足，玻璃体腔内治疗药物的疗效往往不理想。在过去的几十年中，已经应用工程纳米颗粒进行特定组织的靶向治疗。在这篇综述中，我们总结了最近利用玻璃体腔纳米颗粒将治疗药物递送到视网膜的研究。本文强调了临床前研究中的成就和该领域中仍然存在的挑战。还根据提出的药代动力学模型，系统地讨论了包括大小、电荷、稳定性和修饰配体选择在内的参数对眼内分布和转运的影响。我们为针对视网膜的玻璃体腔纳米颗粒的靶向递药提供了合理设计原则的见解。
