Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, 438 Jiefang Rd., Zhenjiang, 212001, Jiangsu, China.
Cell Mol Life Sci. 2019 Jun;76(11):2031-2042. doi: 10.1007/s00018-019-03060-1. Epub 2019 Mar 14.
Pyroptosis is a caspase-1 or caspase-4/5/11-dependent programmed cell death associated with inflammation, which is initiated by inflammasomes or cytosolic LPS in innate immunity. Sepsis is a life-threatening organ dysfunction caused by an imbalance in the body's response to infection. It is a complex interaction between the pathogen and the host's immune system. Neutrophils play the role of a double-edged sword in sepsis, and a number of studies have previously shown that regulation of neutrophils is the most crucial part of sepsis treatment. Pyroptosis is one of the important forms for neutrophils to function, which is increasingly understood as a host active immune response. There is ample evidence that neutrophil pyroptosis may play an important role in sepsis. In recent years, a breakthrough in pyroptosis research has revealed the main mechanism of pyroptosis. However, the potential value of neutrophil pyroptosis in the treatment of sepsis did not draw enough attention. A literature review was performed on the main mechanism of pyroptosis in sepsis and the potential value of neutrophils pyroptosis in sepsis, which may be suitable targets for sepsis treatment in future.
细胞焦亡是一种由半胱天冬酶-1 或半胱天冬酶-4/5/11 所依赖的、与炎症相关的程序性细胞死亡，其由先天免疫中的炎性小体或胞质内 LPS 所引发。脓毒症是一种由机体对感染的反应失衡所导致的危及生命的器官功能障碍，是病原体与宿主免疫系统之间的复杂相互作用。中性粒细胞在脓毒症中扮演着双刃剑的角色，许多研究先前表明，对中性粒细胞的调控是脓毒症治疗的最关键部分。细胞焦亡是中性粒细胞发挥功能的重要形式之一，其作为一种宿主主动免疫反应的概念正逐渐被理解。大量证据表明中性粒细胞焦亡可能在脓毒症中发挥重要作用。近年来，细胞焦亡研究的突破揭示了细胞焦亡的主要机制，但中性粒细胞焦亡在脓毒症治疗中的潜在价值尚未引起足够重视。本文就脓毒症中细胞焦亡的主要机制以及中性粒细胞焦亡在脓毒症中的潜在价值进行综述，其可能成为未来脓毒症治疗的合适靶点。
