巨噬细胞焦亡及其在急性肺损伤/急性呼吸窘迫综合征中的关键作用。

Macrophage pyroptosis and its crucial role in ALI/ARDS.

作者信息

Cai Yuju, Shang Luorui, Zhou Fangyuan, Zhang Mengqi, Li Jinxiao, Wang Shuhan, Lin Qifeng, Huang Jianghua, Yang Shenglan

机构信息

Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Front Immunol. 2025 Feb 14;16:1530849. doi: 10.3389/fimmu.2025.1530849. eCollection 2025.

DOI:10.3389/fimmu.2025.1530849

PMID:40028334

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11867949/

Abstract

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to lung injury. However, the pathogenesis of ALI/ARDS remains a complex issue. In recent years, the role of macrophage pyroptosis in lung injury has garnered extensive attention worldwide. This paper reviews the mechanism of macrophage pyroptosis, discusses its role in ALI/ARDS, and introduces several drugs and intervening measures that can regulate macrophage pyroptosis to influence the progression of ALI/ARDS. By doing so, we aim to enhance the understanding of the mechanism of macrophage pyroptosis in ALI/ARDS and provide novel insights for its treatment.

摘要

急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）是一种严重的临床综合征，其发病率和死亡率高，主要是由于肺损伤所致。然而，ALI/ARDS的发病机制仍然是一个复杂的问题。近年来，巨噬细胞焦亡在肺损伤中的作用在全球范围内受到广泛关注。本文综述了巨噬细胞焦亡的机制，讨论了其在ALI/ARDS中的作用，并介绍了几种可调节巨噬细胞焦亡以影响ALI/ARDS进展的药物和干预措施。通过这样做，我们旨在加深对ALI/ARDS中巨噬细胞焦亡机制的理解，并为其治疗提供新的见解。